The 5 Most Effective Treatments for Psoriatic Arthritis

Psoriatic arthritis (PsA) is a chronic inflammatory condition that affects both the skin and joints. It’s a type of arthritis linked to the skin condition psoriasis. While there is no cure for PsA, several treatments can help manage symptoms and prevent joint damage. Here are the five most effective treatments for Psoriatic Arthritis:

  1. Disease-Modifying Antirheumatic Drugs (DMARDs)

    DMARDs are prescription medications designed to slow the progression of PsA and prevent joint damage. One of the most commonly used DMARDs is Methotrexate. It’s not only cost-effective but also beneficial for both skin and joint symptoms. Methotrexate works by suppressing the immune system, which reduces inflammation in the joints and skin. [Source: Mayo Clinic & GoodRx]

  2. Biologic Therapies

    Biologics are a newer class of DMARDs that target specific parts of the immune system. Ustekinumab (Stelara) is one such biologic approved for the treatment of moderate to severe psoriatic arthritis in adults. Biologics are often used when traditional DMARDs are ineffective. They can be highly effective, especially for those with severe symptoms. [Source:]

  3. Cyclosporine

    Cyclosporine is an immunosuppressant drug that can be effective in treating PsA. It works by suppressing the immune system, similar to methotrexate. Adding cyclosporine to methotrexate may enhance the effectiveness of the treatment. However, it’s essential to be aware of potential side effects, including reduced kidney function. [Source: UpToDate]

  4. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

    NSAIDs, such as ibuprofen and naproxen, can help reduce pain and inflammation associated with PsA. They are often the first line of treatment for mild symptoms. While they don’t slow the progression of the disease, they can provide significant relief from pain and swelling.

  5. Interprofessional Approach

    Managing PsA effectively often requires a comprehensive approach that addresses both joint and skin symptoms. This might involve a team of healthcare professionals, including rheumatologists, dermatologists, and physical therapists. An interprofessional approach ensures that all aspects of the disease are addressed, leading to better overall outcomes. [Source: NCBI Bookshelf]


While living with Psoriatic Arthritis can be challenging, advancements in treatments offer hope for those affected. It’s crucial to work closely with a healthcare professional to determine the best treatment plan tailored to individual needs. With the right approach, it’s possible to manage symptoms effectively and lead a fulfilling life.